Wobenzym N use, dosage, side effects, FAQ - MedicinFAQ (2023)

Wobenzym NTablet

Bromelain is a protease enzyme obtained from pineapple stems that consists of a mixture of various thiol endopeptidases and other components such as phosphatase, glucosidase, peroxidase, cellulase, echarase and several protease inhibitors. It works by selectively inhibiting the biosynthesis of pro-inflammatory prostaglandins, and also has analgesic, anticancer and proapoptotic properties. Bromelain has potential therapeutic efficacy in the treatment of conditions such as angina, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered a safe food supplement.

Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, that is, the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is an important component of pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in the presence of trypsin. Chymotrypsin is the most abundant pancreatic protease, which accounts for up to 10-20% of the total proteins synthesized by the exocrine pancreas. Chymotrypsin contains both a catalytic triad and an oxyanion hole, and the tertiary structure of chymotrypsin is similar to that of trypsin.

Chymotrypsin is a digestive enzyme synthesized in the pancreas that plays a key role in proteolysis, or the breakdown of proteins and polypeptides. As a component of pancreatic juice, chymotrypsin supports protein digestion in the duodenum by preferentially cleaving peptide amide bonds.

Pancreatin is a preparation of pancreatin with enzymatic activity of protease, lipase and amylase. Pancreatin hydrolyzes fat into glycerol and fatty acids, converts proteins into proteoses and derivatives, and converts starch into dextrins and sugars. Pancreatin is used in diseases in which the secretion of pancreatic juice is disturbed.

The biggest problems with poor digestion/malabsorption are due to incomplete fat digestion. In clinical studies, the application of pancrelipase as a mixture of amylase, lipase and protease showed a significant improvement in lipid absorption coefficient and nitrogen absorption. These effects are associated with an increase in body weight and body mass index.

Papain, also known as papaya proteinase I, is a cysteine ​​protease enzyme (EC 3.4.22.2) found in papaya species, Carica papaya and Vasconcellea cundinamarcensis. The enzyme was found to be localized in the peel of papaya and is obtained as crude latex from excised unripe papaya. Papain is used in the food, pharmaceutical, textile and cosmetic industries. While it is used to treat inflammation and pain by topical application, it has also been shown to have anthelmintic and teeth whitening properties. It is found in the compositions of various digestive enzymes that are sold without a prescription, and in its active site it contains a catalytic dyad that plays a role in breaking peptide bonds. Papain is also used as an ingredient in various enzymatic debridement preparations.

Papain is a digestive enzyme and often acts as a skin allergen.

user

Bromelain is a protease useful for treating inflammation and removing scabs.

Chymotrypsin is a digestive enzyme dietary supplement used as an adjunctive therapy to manage the side effects of conventional chemotherapy, radiation therapy, and hormone therapy.

There are no therapeutic indications.

Kinder:

• Decreased or absent exocrine secretion from the pancreas
• cystic fibrosis

Adult:

In diseases with impaired exocrine function of the pancreas, such as

• After pancreatectomy
• After total gastrectomy
• Chronic pancreatitis
• Steator
• somatostatinom
• celiac disease

Papain is a proteolytic enzyme obtained from papaya and is used for its anti-inflammatory properties.

There are no FDA-approved therapeutic indications.

Wobenzym N is also used in the adjunctive treatment of these conditions: swelling, ehar removal, colorectal cancer, squamous cell carcinoma of the head and neck, locally advanced cervical cancer, locally advanced non-small cell lung cancer, multiple myeloma (MM), primary non-small cell myeloma - metastatic, breast cancer aerophagia, digestive enzyme deficiency, diarrhea, dyspepsia, exocrine pancreatic insufficiency, flatulence, gastrointestinal discomfort, pancreatic insufficiency, postoperative flatulence, preoperative flatulence, fat malabsorption, flatulence, biliary carbohydrate digestion, biliary carbohydrate digestion, phases. Metabolism, protein digestion, inflammation

How Wobenzym N works

Chymotrypsin is synthesized by pancreatic acinar cells as an inactive precursor, chymotrypsinogen, which is secreted into the duodenum and activated by trypsin-induced cleavage. It also causes its own activation by cleaving essential amino acid residues in the oxyanion cleft to produce α-chymotrypsin, which is a more stable form than π-chymotrypsin. Residues His-57, Asp-102, and Ser-195 form the catalytic triad, while residues 189-195, 214-220, and 225-228 form the primary substrate binding pocket, called the S1 binding pocket. Residue 189 in the polar serine residue at the bottom of the S1 binding pocket. Chymotrypsin prefers aromatic residues such as phenylalanine, tyrosine, and tryptophan, but can hydrolyze other bonds in peptides more slowly.

Pancrelipase is used to compensate for pancreatic enzyme deficiency. As mentioned above, pancrelipase is a mixture of lipase, protease and amylase that can break down fats, proteins and starches in the small intestine. A more detailed description of the individual mechanisms of action can be found under pancrelipase amylase, pancrelipase protease and pancrelipase lipase.

When applied topically, papain elicits an allergen-like inflammatory response by recruiting neutrophils, mast cells, and CD3+ cells and inducing a TH2-dependent antibody response.In vitropapain treatment disrupted the tight junctions of primary human keratinocytes that maintain epithelial barrier integrity. These tight junction proteins include zonula occludens-1, claudin-4, and occludin. Papain is believed to induce allergic reactions via TLR4 activation, leading to an increase in neutrophils, CD3+ cells, mast cells, and CCL8-positive cells.

Wobenzym N

Structure

dosage

Dosage of Wobenzym N

1-3 tablets per day with a meal or as recommended by the doctor.

side effects

Pancreatin can cause sensitivity of the buccal and perianal mucosa, especially in infants. Hypersensitivity reactions have been reported; It can be sneezing, tearing or a rash.

toxicity

No toxicokinetic data available.

Studies on the toxicology of pancrelipase are not necessary since this drug has been used in the clinic for a long time. Clinical overdose studies have shown no effects on the lungs, pancreas, liver and kidneys, but symptoms such as diarrhea or stomach upset may occur. Carcinogenicity studies did not show an increased incidence with the use of pancrelipase. Since pancrelipase is not absorbed, no effects on fetal development or reproduction are expected.

The acute oral LD50 of 200 mcu papain is 4000 mg/kg in rats and 12500 mg/kg in mice. Irritating if inhaled or in contact with eyes.

Caution

In order to avoid temporary indigestion, it is necessary to pay attention to a balanced ratio of fats, proteins and starch.

interaction

Alkaline media destroy the intestinal lining. Therefore, in order to prevent the breakthrough of gastric contents, pancreatin should not be used simultaneously with antacids.

volume of distribution

No pharmacokinetic data available.

Pancrelipase acts locally in the gastrointestinal tract and is not absorbed to a significant extent, therefore the volume of distribution is not important.

No pharmacokinetic data available.

method of elimination

No pharmacokinetic data available.

Pancrelipase acts locally in the gastrointestinal tract and is not absorbed in a significant amount.

No pharmacokinetic data available.

Half a life

No pharmacokinetic data available.

Pancrelipase acts locally in the gastrointestinal tract and is not absorbed to a significant extent, so the elimination half-life is not relevant.

No pharmacokinetic data available.

scope

No pharmacokinetic data available.

Pancrelipase acts locally in the gastrointestinal tract and is not absorbed to a significant extent, so the rate of clearance is not relevant.

No pharmacokinetic data available.

method of elimination

No pharmacokinetic data available.

Pancrelipase is completely excreted in the stool.

No pharmacokinetic data available.

Use during pregnancy and breastfeeding

Pregnancy category C. It is not known whether pancreatin is distributed in milk. Pancreatin should be used with caution.

Acute overdose

Too high a dose may have a laxative effect. No systemic toxicity occurs. Very high doses can cause hyperuricemia and hyperuricosuria.

save mode

Store in a cool and dry place. Keep out of reach of children.

Monographs of innovators

A simplified version can be found hereWobenzym N